Why the study?
Does pretreatment with aspirin and/or clopidogrel reduce cardiac and inflammatory biomarkers in a hypercholesterolemic rat model of acute myocardial infarction?
Population
40 adult male Wistar rats; 32 subjected to hypercholesterolemia and acute myocardial infarction, and 8…
Comparison
Aspirin 30 mg/kg/day orally, clopidogrel 10… vs Hypercholesterolemic rats with induced acute…
Design
Preclinical
Follow-up
7 days of pretreatment followed by 2 days of AMI induction
Authors
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Hypothesis-generating for dual antiplatelet pretreatment in hypercholesterolemic AMI; requires clinical trials before any practice change.
Does pretreatment with aspirin and/or clopidogrel reduce cardiac and inflammatory biomarkers in a hypercholesterolemic rat model of acute myocardial infarction?
In a hypercholesterolemic rat model of acute myocardial infarction, pretreatment with a combination of aspirin and clopidogrel attenuated inflammatory and cardiac injury biomarkers more effectively than either drug alone.
Mohamed et al. (2014) studied this question.
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