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Numerous factors have been shown to affect the metabolism of iron. Evidence has been obtained from experiments with various species of animal that trace elements, such as copper, zinc and molybdenum, may be essential for the metabolic processes of erythropoiesis. Certain other metals, including cobalt, have been mentioned from time to time as stimulating erythropoiesis and causing polycythaemia. Such alterations in erythropoiesis and in production of haemoglobin afford an opportunity for studying the metabolism of body Fe.
McCall et al. (1962) studied this question.
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