Why the study?
Does oral contraceptive use alter renal hemodynamics and increase the risk of developing macroalbuminuria in women with type 1 diabetes?
Population
92 women for the hemodynamic study and an inception cohort of 114 female patients with newly diagnosed type…
Comparison
Oral contraceptive (OC) use vs No oral contraceptive use (OC nonusers)
Design
Cohort
Follow-up
median of 20.7 years for the observational cohort
Authors
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May warrant caution with oral contraceptives in type 1 diabetes; leaves open causal confirmation and need for randomized trials.
Does oral contraceptive use alter renal hemodynamics and increase the risk of developing macroalbuminuria in women with type 1 diabetes?
Oral contraceptive use in women with type 1 diabetes is associated with exaggerated angiotensin-dependent renal vasoconstriction and a significantly increased risk of developing diabetic nephropathy.
Ahmed et al. (2005) studied this question.
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