What question did this study set out to answer?

To determine whether disturbances in heparan sulphate proteoglycans contribute to vascular disease by measuring heparin-induced release of eight endothelium-associated binding proteins in Type 1 diabetes.

September 22, 2004Diabetic Medicine

Release of endothelium‐associated proteins into blood by injection of heparin in normal subjects and in patients with Type 1 diabetes

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Authors

BMBjarne MyrupUniversity of Copenhagen HYHiroki YokoyamaJikei University School of Medicine OKOle Peter KristiansenFrederiksberg Hospital

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Implication

Comparative study reveals altered heparin-induced release of endothelium-associated proteins in Type 1 diabetes with albuminuria, indicating distinct vascular wall derangements.

Key Points

To determine whether disturbances in heparan sulphate proteoglycans contribute to vascular disease by measuring heparin-induced release of eight endothelium-associated binding proteins in Type 1 diabetes.
Assessed three matched cohorts: Type 1 diabetic patients with albuminuria (n = 10), Type 1 diabetic patients without albuminuria (n = 15), and healthy controls (n = 12).
Administered 40 anti-Xa IU/kg low molecular weight heparin intravenously, collecting blood samples pre-injection and 5 minutes post-injection to measure protein levels.
Lipoprotein lipase increased significantly more in diabetic patients without albuminuria [261 (170–293) mU/ml] compared to controls [177 (103–438) mU/ml, P < 0.05] and diabetic patients with albuminuria [203 (159–280) mU/ml, P < 0.05].
Total tissue factor pathway inhibitor increased more in diabetic patients with [284 (198–449) ng/ml] and without albuminuria [275 (243–399) ng/ml] than in controls [221 (169–289) ng/ml, P < 0.005].
Vitronectin increased significantly only in diabetic patients with albuminuria, whereas antithrombin, von Willebrand factor, and fibronectin did not increase significantly, and extracellular superoxide dismutase and platelet factor 4 increased equally across all groups.

Cite This Study

Myrup et al. (2004) studied this question.

synapsesocial.com/papers/6a7e262dba7d678347fa14f3 https://doi.org/10.1111/j.1464-5491.2004.01313.x

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Implication

Comparative study reveals altered heparin-induced release of endothelium-associated proteins in Type 1 diabetes with albuminuria, indicating distinct vascular wall derangements.

Release of endothelium‐associated proteins into blood by injection of heparin in normal subjects and in patients with Type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Release of endothelium‐associated proteins into blood by injection of heparin in normal subjects and in patients with Type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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