August 1, 1996Canadian Journal of Physiology and Pharmacology

Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes

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Population

Calcium-tolerant isolated cardiomyocytes from rat ventricle

Design

Preclinical

Follow-up

20 minutes

Authors

ECEh Chan MTM J ThomasNational Research Centre BBBrian BandyUniversity of Saskatchewan

Discussion

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Implication

May signal acute free radical cardiotoxicity risk with anthracyclines; hypothesis-generating and should not change practice.

Structured PICO

Population

Calcium-tolerant isolated cardiomyocytes from rat ventricle

Intervention

Doxorubicin and 4'-epirubicin (10 microM for 20 min), with or without antioxidant enzymes (superoxide dismutase 10 U/mL or catalase 10 U/mL)

Outcome

Contractility indices (maximum extent of cell shortening, peak shortening velocity, and peak relaxation velocity of single twitches)surrogate

Both doxorubicin and 4'-epirubicin acutely depress cardiomyocyte contractility to a similar extent, likely mediated by a free radical mechanism involving hydrogen peroxide.

Cite This Study

Chan et al. (1996) studied this question.

synapsesocial.com/papers/6a7e27f03d987f2790256ab0 https://doi.org/10.1139/y96-091

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Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider