Why the study?
Dose-dependent cardiotoxicity from doxorubicin may cause heart failure via free radical generation, and Murraya koenigii leaf extract possesses antioxidant properties that may provide cardioprotection.
Does Murraya koenigii leaf extract prevent doxorubicin-induced cardiotoxicity in rats?
Population
Five groups of rats with 10 animals in each group
Comparison
Murraya leaf extract vs doxorubicin alone vs dexrazoxane vs normal control
Design
Randomized preclinical animal study
Authors
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Should not change doxorubicin management; hypothesis-generating for Murraya extract cardioprotection in animal models.
Does Murraya koenigii leaf extract prevent doxorubicin-induced cardiotoxicity in rats?
Murraya koenigii leaf extract demonstrates cardioprotective, antioxidant, and anti-inflammatory effects against doxorubicin-induced cardiotoxicity in a rat model.
Sandamali et al. (2020) studied this question.
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