Why the study?
Does nebivolol attenuate ischemia-induced metabolic changes in anesthetized open chest dogs?
Population
Anesthetized open chest dogs with ischemia induced by ligating the left anterior descending coronary artery
Comparison
IV injection of dl-nebivolol, or d- or… vs Vehicle
Design
Preclinical
Follow-up
3 minutes of ischemia
Authors
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Hypothesis-generating for nebivolol's beta-blockade-mediated metabolic effects in ischemia; leaves open human translation.
Does nebivolol attenuate ischemia-induced metabolic changes in anesthetized open chest dogs?
dl-Nebivolol lessens ischemic derangement of myocardial metabolism in a canine model, primarily through its beta-adrenergic blocking properties rather than endothelium-dependent vasorelaxation.
Satoh et al. (2003) studied this question.
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