February 13, 2004Journal of Medical Virology

Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: Results from the EPIVIR project

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Why the study?

Is there a correlation between the incidence of type 1 diabetes and the frequency of enterovirus infections in different European populations?

Population

1-year-old and 10-14-year-old children in seven European countries

Comparison

Enterovirus infection vs Comparison between countries with high diabetes…

Design

Cross-sectional

Authors

HVHanna ViskariTampere University JLJohnny LudvigssonLinköping University RURaivo UiboUniversity of Tartu

Discussion

Member takes

Implication

Supports polio hypothesis for type 1 diabetes; hypothesis-generating and does not yet inform clinical practice.

Structured PICO

Is there a correlation between the incidence of type 1 diabetes and the frequency of enterovirus infections in different European populations?

Population

1-year-old and 10-14-year-old children in seven European countries (Finland, Sweden, Estonia, Germany, Hungary, Lithuania, Russia)

Intervention

Enterovirus infection (assessed by enterovirus antibodies using EIA and neutralisation assays)

Comparator

Comparison between countries with high diabetes incidence (Finland, Sweden) and low/intermediate incidence (Estonia, Germany, Hungary, Lithuania, Russia)

Outcome

Frequency of enterovirus antibodiessurrogate

There is an inverse correlation between the incidence of type 1 diabetes and enterovirus infections in the background population, supporting the polio hypothesis.

Cite This Study

Viskari et al. (2004) studied this question.

synapsesocial.com/papers/6a7e2ac0b42418cb2c83e017 https://doi.org/10.1002/jmv.20033

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