Population
Post-myocardial infarction (MI) rat heart model
Comparison
In vivo blockade of RAS by AT1 receptor blocker… vs Untreated post-MI rats
Design
Preclinical
Follow-up
Up to 7 days post-MI
Authors
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JAK2 blockade may increase post-MI apoptosis despite PP1 benefits; leaves open net therapeutic value and requires human validation.
The JAK-STAT pathway is activated early post-MI and linked to the angiotensin II autocrine loop; its selective inhibition modifies remodeling but may increase apoptosis.
H El-Adawi (2002) studied this question.
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