October 1, 1997Immunological Reviews
The role of antibody in recovery from alphavirus encephalitis
Population
Weanling mice infected intracerebrally with Sindbis virus
Design
Preclinical
Authors
Discussion
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Implication
Non-lytic E2 antibody clearance in alphavirus encephalitis supports mechanistic studies; leaves open human translation pending clinical evidence.
Structured PICO
P
Population
Weanling mice infected intracerebrally with Sindbis virus (virulent NSV strain or less virulent SV AR339 strain)
I
Intervention
Neutralizing and non-neutralizing antibodies to the E1 and E2 surface glycoproteins
O
Outcome
Protection from fatal disease and clearance of virus from the nervous system
Antibodies to E1 and E2 glycoproteins protect mice from fatal alphavirus encephalitis and clear the virus via a non-lytic mechanism.
Cite This Study
Griffin et al. (1997) studied this question.