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March 23, 2012CirculationOpen Access

Comparative Outcomes for Patients Who Do and Do Not Undergo Percutaneous Coronary Intervention for Stable Coronary Artery Disease in New York

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Why the study?

Does PCI with routine medical treatment reduce mortality or MI compared to routine medical treatment alone in patients with stable coronary artery disease?

Population

Patients with stable coronary artery disease undergoing cardiac catheterization in New York State between…

Comparison

Percutaneous coronary intervention combined with… vs Routine medical treatment (RMT) alone

Design

Cohort

Follow-up

4 years

Authors

EHEdward L. HannanInterventional CardiologyZSZaza SamadashviliUniversity at Albany, State University of New YorkKCKimberly CozzensAlbany State University

Discussion

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Member takes

Implication

Should not change practice in stable CAD; leaves open confirmation of PCI benefit in randomized trials.

Structured PICO

Does PCI with routine medical treatment reduce mortality or MI compared to routine medical treatment alone in patients with stable coronary artery disease?

P
Population
Patients with stable coronary artery disease undergoing cardiac catheterization in New York State between 2003 and 2008 (propensity-matched cohort of 933 pairs, n=1,866).
I
Intervention
Percutaneous coronary intervention (PCI) combined with routine medical treatment (RMT)
C
Comparator
Routine medical treatment (RMT) alone
O
Outcome
Composite of mortality or myocardial infarction (MI) at 4 yearscomposite

In a real-world propensity-matched cohort, PCI combined with routine medical therapy was associated with lower mortality and MI rates at 4 years compared to medical therapy alone in patients with stable CAD.

Limitations

  • Possible role of low medication adherence rates confounding the results

Cite This Study

Hannan et al. (2012) studied this question.

synapsesocial.com/papers/6a7e2fbf16134f106bf71077https://doi.org/10.1161/circulationaha.111.071811

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in Coronary Artery Disease2006 · 508 citations
  2. 2Patterns and Intensity of Medical Therapy in Patients Undergoing Percutaneous Coronary Intervention2011 · 191 citations
  3. 3Medication Adherence2009 · 1,491 citations
  4. 4Optimal Matching for Observational Studies1989 · 123 citations