November 7, 2005British Journal of PharmacologyOpen Access

Angiotensin II and angiotensin II receptor blocker modulate the arrhythmogenic activity of pulmonary veins

View Full Paper

Ask AI

Bookmark

Why the study?

Does angiotensin II or losartan modulate the arrhythmogenic activity of pulmonary veins in isolated rabbit tissue?

Population

Isolated rabbit pulmonary vein tissue and single cardiomyocytes

Comparison

Angiotensin II or losartan vs Baseline

Design

Preclinical

Authors

YCYi‐Jen ChenElectrophysiology YCYi‐Jen ChenElectrophysiology CTChing‐Tai TaiNational Yang Ming Chiao Tung University

Discussion

Member takes

Implication

May support ARB benefit in AF via pulmonary vein effects; hypothesis-generating and should not change practice.

Structured PICO

Does angiotensin II or losartan modulate the arrhythmogenic activity of pulmonary veins in isolated rabbit tissue?

Population

Isolated rabbit pulmonary vein tissue and single cardiomyocytes

Intervention

Angiotensin II (1, 10, and 100 nM) or losartan (1 and 10 microM)

Comparator

Baseline (before administering angiotensin II or losartan)

Outcome

Action potentials (APs) and ionic currentssurrogate

Angiotensin II and AIIRBs modulate pulmonary vein electrical activity, providing a potential mechanistic explanation for the clinical observation that AIIRBs help prevent atrial fibrillation.

Cite This Study

Chen et al. (2005) studied this question.

synapsesocial.com/papers/6a7e30738129fc77b4b2985a https://doi.org/10.1038/sj.bjp.0706445

View Full Paper

Ask AI

Bookmark

Angiotensin II and angiotensin II receptor blocker modulate the arrhythmogenic activity of pulmonary veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II and angiotensin II receptor blocker modulate the arrhythmogenic activity of pulmonary veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider