November 25, 2025CureusOpen Access

When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

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Why the study?

Exertional rhabdomyolysis is a potentially life-threatening condition that can occur in previously healthy individuals undertaking unaccustomed high-intensity exercise.

Population

A 20-year-old male presenting with severe exertional rhabdomyolysis following increased gym activity

Design

Case report

Authors

WTWardah TariqUniversity Hospitals of Leicester NHS Trust HKHabeeb Kamal ANAung NaingThe University of Texas MD Anderson Cancer Center

Discussion

Member takes

Implication

Aggressive IV fluids may avert AKI despite extreme CK in rhabdomyolysis; hypothesis-generating, requires prospective validation.

Structured PICO

Population

20-year-old male with a history of depression presenting with severe exertional rhabdomyolysis (muscle soreness, dysuria, dark urine) following unaccustomed high-intensity gym workouts.

Intervention

Aggressive intravenous hydration (alternating 0.9% normal saline and Hartmann’s solution at 250-300 mL/hour, total volume approximately 32 L over 4 days).

Outcome

Prevention of acute kidney injury and normalization of creatine kinase levelssurrogate

Prompt and aggressive intravenous fluid resuscitation can prevent acute kidney injury in severe exertional rhabdomyolysis, even when creatine kinase levels are exceptionally high.

Cite This Study

Tariq et al. (2025) studied this question.

synapsesocial.com/papers/6a7e30d48d19188c2c856233 https://doi.org/10.7759/cureus.97811

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When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

Discussion

Member takes

Implication

Structured PICO

Cite This Study

When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider