Why the study?
Do ACE inhibitors, AT1 antagonists, or their combination prevent the progression of chronic renal disease?
Population
Patients with chronic renal disease, including type 1 and type 2 diabetes with nephropathy, hypertensive…
Comparison
Angiotensin-converting enzyme inhibitors… vs Placebo or other antihypertensive drugs.
Design
Review
Authors
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May support ACE inhibitors to slow CKD progression in select nephropathies; leaves open roles of AT1 antagonists and combinations for prospective trials.
Do ACE inhibitors, AT1 antagonists, or their combination prevent the progression of chronic renal disease?
ACE inhibitors significantly reduce the risk of progression in various chronic kidney diseases, while the distinct pathophysiological mechanisms of AT1 antagonists and combination therapies warrant further clinical evaluation.
Hilgers et al. (2002) studied this question.
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