What question did this study set out to answer?

Identify the bacterial lineages responsible for the post-PCV13 emergence of Streptococcus pneumoniae serotype 24F in France and contextualize their evolutionary dynamics globally.

August 16, 2022The Lancet MicrobeOpen Access

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

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Authors

SLStephanie W. LoGreat Ormond Street Hospital KMKate C. MellorWellcome Sanger Institute RCRobert CohenEnzo Life Sciences (United States)

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Implication

International whole-genome sequencing study reveals a multidrug-resistant pneumococcal lineage drives serotype replacement in children, highlighting challenges for serotype-targeted vaccines.

Key Points

Identify the bacterial lineages responsible for the post-PCV13 emergence of Streptococcus pneumoniae serotype 24F in France and contextualize their evolutionary dynamics globally.
Sequenced whole genomes of serotype 24F pneumococcal isolates from pediatric asymptomatic carriage (n=229) and invasive disease (n=190) collected in France between 2003 and 2018.
Assigned Global Pneumococcal Sequence Clusters (GPSCs) and clonal complexes to each isolate and performed phylogenetic and spatiotemporal analyses incorporating a global reference dataset of 25,590 pneumococcal genomes.
Global expansion of serotype 24F was driven primarily by lineages GPSC10 (CC230), GPSC16 (CC156), and GPSC206 (CC7701), with GPSC10 identified as the sole multidrug-resistant lineage and the primary driver of invasive 24F disease in France.
Analysis of 888 global GPSC10 genomes showed expression of 16 different serotypes (only six covered by PCV13), distinct monophyletic clustering of all 24F isolates, transmission across France within 3–5 years, and intercontinental spread.

Cite This Study

Lo et al. (2022) studied this question.

synapsesocial.com/papers/6a7e34c3196d67da7483e119 https://doi.org/10.1016/s2666-5247(22)00158-6

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Implication

International whole-genome sequencing study reveals a multidrug-resistant pneumococcal lineage drives serotype replacement in children, highlighting challenges for serotype-targeted vaccines.

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Discussion

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Implication

Key Points

Cite This Study

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Discussion

Member takes

Implication

Key Points

Cite This Study

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