Why the study?
Does steroid treatment reduce serum triglycerides in a patient with SLE and extreme hypertriglyceridemia?
Does steroid treatment reduce serum triglycerides in a patient with SLE and extreme hypertriglyceridemia?
Steroid treatment can dramatically reduce extreme hypertriglyceridemia in patients with systemic lupus erythematosus, possibly by correcting deficient lipoprotein lipase activity.
Steroid therapy may reduce extreme hypertriglyceridemia in SLE; leaves open confirmation beyond this single case.
Only a few cases of hypertriglyceridemia in patients with systemic lupus erythematosus (SLE) have been reported. We report a case of a 13-year-old girl suffering from SLE associated with severe hypertriglyceridemia. The persistent hypertriglyceridemia was extremely well tolerated. As a result of steroid treatment, serum triglycerides fell dramatically from a high of 5601 mg/dL to 75 mg/dL despite the patient switching to a free diet. We considered the presence of an autoantibody to lipoprotein lipase and commenced immunosuppression. The role of steroids in completely correcting deficient lipoprotein lipase activity is discussed.
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Huang et al. (2008) studied this question.
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