Routine Immunohistology in Renal Diseases

Article1 January 1966Routine Immunohistology in Renal DiseasesK. LANGE, M.D., F.A.C.P., G. TRESER, M.D., I. SAGEL, M.D., A. TY, M.D., E. WASSERMAN, M.D.K. LANGE, M.D., F.A.C.P.Search for more papers by this author, G. TRESER, M.D.Search for more papers by this author, I. SAGEL, M.D.Search for more papers by this author, A. TY, M.D.Search for more papers by this author, E. WASSERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-25 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1907 it was suggested (1) that certain renal diseases may be caused by an immune reaction involving the glomerulus. This hypothesis has recently received renewed support. In 1951 we demonstrated the presence of antibodies against human kidney tissue emulsion in a group of patients with chronic glomerulonephritis (2). Studies revealing a lowering of serum complement activity in patients with acute glomerulonephritis, systemic lupus erythematosus, and nephrosis (3-7) lend added support to the possibility that an immune mechanism may be responsible for these diseases. Using an immunofluorescent technique on autopsy material from patients with glomerulonephritis, Mellors and Ortega (8) have...References1. SCHICK B: Die Nachkrankheiten des Scharlach. Jb. Kinderheilk. 65: 132, 1907. Google Scholar2. LANGEGOLDWEINERSIMON KMMDV: Autoantibodies in human glomerulonephritis. J. Clin. Invest. 28: 50, 1949. CrossrefGoogle Scholar3. VEILBUCHHOLZ WHB: Der Komplementschwund im Blute. Klin. Wschr. 11: 2019, 1932. CrossrefGoogle Scholar4. KELLETT CE: Complement titre in acute nephritis. Lancet 2: 1262, 1936. CrossrefGoogle Scholar5. VAUGHANBAYLESFAVOUR JHTBCB: Complement in disseminated systemic-lupus-erythematosus. J. Lab. Clin. Med. 37: 698, 1951. MedlineGoogle Scholar6. LANGESLOBODYGRAIGOGUROBERMANLO-CASTO KLFGJF: Serum complement in acute glomerulonephritis and the nephrotic syndrome. Pediatrics 8: 814, 1951. MedlineGoogle Scholar7. LANGEWASSERMANSLOBODY KELB: The significance of serum complement levels for the diagnosis and prognosis of acute and subacute glomerulonephritis and lupus erythematosus disseminatus. Ann. Intern. Med. 53: 636, 1960. LinkGoogle Scholar8. MELLORSORTEGA RCLG: Analytical pathology III. New observations on pathogenesis of glomerulonephritis, lipid nephrosis, periarteritis nodosa and secondary amyloidosis in man. Amer. J. Path. 32: 455, 1956. MedlineGoogle Scholar9. FREEDMANPETERSKARK PJHRM: Localization of gamma globulin in the diseased kidney. Arch. Intern. Med. (Chicago) 105: 524, 1960. CrossrefMedlineGoogle Scholar10. BURKHOLDER PM: Complement fixation in diseased tissues. I. Fixation of guinea pig complement in sections of kidney from humans with membraneous glomerulonephritis and rats injected with anti-rat kidney serum. J. Exp. Med. 114: 605, 1961. CrossrefMedlineGoogle Scholar11. FREEDMANMARKOWITZ PAS: Gamma globulin and complement in the diseased kidney. J. Clin. Invest. 41: 328, 1962. CrossrefMedlineGoogle Scholar12. SCHÄFERSCHÄFER HEA: Diagnostische Bedeutung der Serum-Komplementactivität bei Nierenerkrankungen. Verh. Deutsch. Ges. Inn. Med. 69: 725, 1963. Google Scholar13. MICHAELDRUMMONDVERNIERGOOD AFKNRLRA: Immunologic basis of renal disease. Pediat. Clin. N. Amer. 11: 685, 1964. CrossrefMedlineGoogle Scholar14. LANGEWENKNOBLEWACHSTEIN KEJM: The mechanism of experimental glomerulonephritis produced in rabbits by avian anti-kidney sera. Amer. J. Med. Sci. 236: 767, 1958. CrossrefMedlineGoogle Scholar15. RIGGSLOHEVELAND JLPCWC: A simple fractionation method for preparation of fluorescein-labeled gamma globulin. Proc. Soc. Exp. Biol. Med. 105: 655, 1960. CrossrefMedlineGoogle Scholar16. KLEINCOLLI GPA: Herstellung und Auswertung von Antikomplement. Z. Hyg. Infektionskr. 147: 201, 1961. MedlineGoogle Scholar17. MÜLLER-EBERHARDNILSSONARONSSON HJUT: Isolation and characterization of two β1 glycoproteins of human serum. J. Exp. Med. 111: 201, 1960. CrossrefMedlineGoogle Scholar18. TRESERSAGELLANGE GIK: Specificity of immunofluorescence in experimental and human renal diseases. Proc. Soc. Exp. Biol. Med. 117: 842, 1964. CrossrefMedlineGoogle Scholar19. LANGEORESSTRAUSSWACHSTEIN KROWM: Steroid therapy of systemic lupus erythematosus based on immunologic considerations. Arthritis Rheum. 8: 244, 1965. CrossrefMedlineGoogle Scholar20. LANGESTRANGSLOBODYWENK KRLBEJ: The treatment of the nephrotic syndrome with steroids in children and adults. Arch. Intern. Med. (Chicago) 99: 760, 1957. CrossrefGoogle Scholar21. LANGE K: The Glucocorticoid Therapy of Pure Nephrosis and the Nephritic Stage of Chronic Glomerulonephritis, Vol. II. 1623 pages. Proceedings of the 3rd International Congress for Chemotherapy. Georg Thieme Verlag, Stuttgart, 1963. Google Scholar22. LANGEWACHSTEINWASSERMANALPTEKINSLOBODY KMEFLB: The congenital nephrotic syndrome, an immune reaction? Amer. J. Dis. Child. 105: 338, 1963. CrossrefMedlineGoogle Scholar23. SCHÄFERSCHÄFER HEA: Aspekte zur Immunpathogenese der malignen Hypertonie. Med. Welt 1144, 1965. MedlineGoogle Scholar24. SEEGALHSUFIASCHIANDRES BCKCEG: La tecnica degli anticorpi fluorescenti applicata allo studio della patogenesi della nefrite umana. Rass. Fisiopat. Clin. Ter. 31: 1, 1959. MedlineGoogle Scholar25. MARKOWITZLANGE ASCF: Streptococcal related glomerulonephritis. I. Isolation immunochemistry and comparative chemistry of soluble fractions from type 12 nephritogenic streptococci and human glomeruli. J. Immun. 92: 565, 1964. MedlineGoogle Scholar26. LACHMANMÜLLER-EBERHARDKUNKELPARONETTO PJHJHGF: The localization of in vivo bound complement in tissue sections. J. Exp. Med. 115: 63, 1962. CrossrefMedlineGoogle Scholar27. GRISHMANPORUSH EJ: Electron microscopic studies of "minimal" lupus nephritis. Fed. Proc. 23: 446, 1964. Google Scholar28. DIXONFELDMANVAZQUEZ FJJDJJ: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. Exp. Med. 113: 899, 1961. CrossrefMedlineGoogle Scholar29. WESTNORTHWAYDAVIS CDJDNC: Serum levels of β1e globulin, a complement component in the nephritides, lipoid nephrosis and other conditions. J. Clin. Invest. 43: 1507, 1964. CrossrefMedlineGoogle Scholar30. DAMMINMERRILL JGJP: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: K. LANGE, M.D., F.A.C.P.; G. TRESER, M.D.; I. SAGEL, M.D.; A. TY, M.D.; E. WASSERMAN, M.D.Affiliations: New York, New YorkFrom the Renal Service and Laboratory, Departments of Medicine and Pediatrics, New York Medical College, New York, N. Y.This study was supported by grant A-302 (C7-12) from the Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md., and grants from the Kidney Disease Foundation of New York.Portions of this study were presented before the Annual Meeting of the American College of Physicians, April 9, 1964, Atlantic City, N. J., and the Annual Meeting of the Association of American Physicians, May 4, 1965, Atlantic City, N. J.Requests for reprints should be addressed to Kurt Lange, M.D., New York Medical College, 1 East 105th St., New York, N. Y. 10029. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntroduction and First Clinical Application of a Simplified Immunohistochemical Validation System Confirms Prognostic Impact of KI-67 and CK20 for Stage T1 Urothelial Bladder Carcinoma: Single-Center Analysis of Eight Biomarkers in a Series of Three Hundred Six PatientsPostmortem Immunofluorescence and Electron Microscopy for Diagnosing Immune Complex DiseaseImmunoalkaline phosphatase technique applied to paraffin wax embedded tissues in diagnostic renal pathology.Intrarenal hemodynamic alterations induced by anti-GBM antibodyDirect antiGBM antibody induced alterations in glomerular permselectivityClinical Significance of Isolated ProteinuriaNo evidence for a specific role of IgM in mesangial proliferation of idiopathic nephrotic syndromeIsolated Proteinuria in Asymptomatic PatientsFocal Segmental Membranous Glomerulonephropathy Associated with Other Glomerular DiseasesIsolated proteinuria in asymptomatic patientsCellular immunity in systemic lupus erythematosus as evidenced in vitro by leucocyte migration inhibition tests.Immunhistologische Befunde bei nicht-glomerulonephritischen NierenerkrankungenAllergic Renal DiseasesSystemic Lupus ErythematosusTHE NEPHROTIC SYNDROME OF INFANCYFAILURE TO DEMONSTRATE IMMUNOGLOBULIN E IN GLOMERULI OF PATIENTS WITH VARIOUS NEPHROPATHIESThe KidneyRoutine immunofluorescent microscopy in renal diseasesElektronenmikroskopische Aspekte der GlomerulonephritisFocal and Segmental Glomerulosclerosis Associated with the Nephrotic Syndrome: Fine Structure, Pathogenetic Aspects and Clinical SignificanceMembranous glomerulonephritis: Long-term serial observations on clinical course and morphologyIdiopathic membranous nephropathy in childrenMembranous Glomerulonephritis Evolution of Clinical and Pathologic FeaturesMELVIN C. GLUCK, M.D., GLORIA GALLO, M.D., LOWENSTEIN JEROME, M.D., DAVID S. BALDWIN, M.D.Untersuchungen zur cellulären Immunreaktion in vitro gegen Nierenantigen bei Patienten mit chronischer NierenentzündungExtramembranous deposits and ?membranous? glomerulonephritisMembranous nephropathy and the nephrotic syndrome in the catMembranous glomerulonephritis: Current statusIMMUNOFLUORESCENT AND MORPHOLOGICAL STUDIES IN CONGENITAL NEPHROTIC SYNDROME 1III. PodiumsgesprächA PARAFFIN EMBEDDING METHOD IN KIDNEY IMMUNOFLUORESCENT STUDIESHereditary nephritis with nerve deafnessZur Klinik und Prognose der Nierenmanifestationen bei Lupus erythematodesIn-vivo nuclear localisation of human antinuclear antibodies in mice with carbon tetrachloride- and thioacetamide-induced hepatic necrosisStudies on the pathogenic action of human antinuclear antibodies: Inflammatory skin reactions in mice to immune complexes formedin vitro from human antinuclear antibodies and human leucocytesBilateral renal hypoplasia with oligonephroniaVascular lesions in human allotransplantated kidneysIMMUNOFLUORESCENT ANTIBODY STUDIES IN DERMATITIS HERPETIFORMISDie Bedeutung immunhistologischer Befunde für die nephrologische DiagnostikLOCALIZATION OF PLASMA PROTEINS IN KIDNEYS OF CHILDREN WITH DIFFUSE NEPHROPATHIES, STUDIED BY AN INDIRECT IMMUNOFLUORESCENT TECHNIQUEAntigenic Streptococcal Components in Acute GlomerulonephritisThe Renal Excretion of Nitrogen Containing MetabolitesNatural History of Lipoid Nephrosis and of Membranous GlomerulonephritisVICTOR E. POLLAK, M.D., F.R.C.P.(EDIN.), SEYMOUR ROSEN, M.D., CONRAD L. PIRANI, M.D., ROBERT C. MUEHRCKE, M.D., F.A.C.P., ROBERT M. KARK, M.D., F.A.C.P., F.R.C.P.Nephropathy Induced by D-PenicillamineISRAELI A. JAFFE, M.D., F.A.C.P., GERHARD TRESER, M.D., YASUNOSUKE SUZUKI, M.D., THEODORE EHRENREICH, M.D.Immune cross-reaction among M. leprae, BCG and human phalanxRole of Lupus Erythematosus Factor and Accessory Serum Factors in Production of Extracellular Nuclear MaterialHARVEY E. GOLDEN, M.D., FREDERIC C. MCDUFFIE, M.D., F.A.C.P.Recent Advances in the Rheumatic DiseasesEPHRAIM P. ENGLEMAN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.Vascular reactivity in essential and renal hypertension in man 1 January 1966Volume 64, Issue 1 Page: 25-40 Keywords Child health Glomerulonephritis Immune serum Kidneys Lupus erythematosus Metabolic disorders Pediatrics Renal diseases Research laboratories Systemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...