This review highlights the diverse and potentially lethal cardiotoxic effects of numerous commonly used drug classes, emphasizing the need for clinical awareness of drug-induced cardiac pathology.
Raises clinician awareness of lethal cardiotoxicity from multiple drug classes; leaves open prospective validation of synergistic risks.
Many commonly used drugs, with each causing changes that may be potentially lethal, can adversely affect the function of the heart. In addition some drugs have synergistic effects that can also damage cardiovascular tissues. The drug-related cardiotoxic effects of antineoplastic agents, psychotropic medications, heavy metals, substances of abuse, promotility agents, antihistamines, antimicrobials and antiarrhythmic agents are discussed. Hypersensitivity myocarditis is also discussed.
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Butany et al. (2009) studied this question.
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