Population
928 consecutive patients receiving 1103 courses of warfarin at five anticoagulation clinics
Design
Cohort
Follow-up
1950 patient-years
Authors
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Supports vigilant INR monitoring during warfarin initiation and in comorbid patients; leaves open whether targeted strategies reduce bleeding events.
High prothrombin time ratio (≥2.0), high PTR variability, recent initiation of therapy, and multiple comorbidities are independent predictors of serious bleeding in patients on chronic warfarin therapy, whereas older age alone is not.
Stephan D. Fihn (1993) studied this question.
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