Cardioprotective effect of a novel cyclohexane dicarboximide derivative, ST-6, against ischemia/reperfusion injury

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Why the study?

Does ST-6 reduce ischemia/reperfusion injury in isolated rat hearts?

Structured PICO

Does ST-6 reduce ischemia/reperfusion injury in isolated rat hearts?

Population

Isolated rat hearts subjected to 30 min of ischemia followed by a 60-min reperfusion

Intervention

ST-6 (a novel cyclohexane dicarboximide derivative) at 10 and 30 μM

Comparator

Untreated control isolated rat hearts subjected to ischemia/reperfusion

Outcome

Postischemic recovery of left ventricular developed pressure and left ventricular end-diastolic pressuresurrogate

ST-6, a novel sodium channel blocker, reduces ischemia/reperfusion injury and attenuates sodium overload in an isolated rat heart model.

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Should not change clinical practice; hypothesis-generating for ST-6 in human ischemia/reperfusion injury.

Takeo et al. (2000) studied this question.

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