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March 1, 1993Cardiovascular Research

Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle

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Why the study?

Does R 56865 prevent Ca2+ overload, arrhythmias, and cell death in myocardial cells?

Population

Myocardial cells in conditions of ischemia/reperfusion and cardiac glycoside intoxication

Design

Review

Authors

LDLuc Ver DonckJohnson & Johnson (United States)MBM. BorgersJanssen (Belgium)

Discussion

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Implication

May support novel antiarrhythmic development targeting Na+ overload; leaves open clinical translation and safety in humans.

Structured PICO

Does R 56865 prevent Ca2+ overload, arrhythmias, and cell death in myocardial cells?

P
Population
Myocardial cells in conditions of ischemia/reperfusion and cardiac glycoside intoxication
I
Intervention
R 56865
O
Outcome
Prevention of Ca2+ overload, arrhythmias, and cell deathsurrogate

R 56865 offers a novel cytoprotective mechanism by preventing Na+ and subsequent Ca2+ overload, thereby protecting against arrhythmias and cell death without negative inotropic effects.

Cite This Study

Donck et al. (1993) studied this question.

synapsesocial.com/papers/6a868cb607201076d3544979https://doi.org/10.1093/cvr/27.3.349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology1991 · 51 citations
  2. 2Characterization of the interaction of R 56865 with cardiac Na‐ and L‐type Ca channels1991 · 13 citations
  3. 3Effects of R56865, an Na+- and Ca2+-Overload Inhibitor, on Myocardial Injury in Ischemic, Reperfused Porcine Hearts1995 · 8 citations
  4. 4Effects of R-56865 on transient inward current, Na(+)-Ca2+ exchange, and Ca2+ release from SR in cardiac myocytes1994 · 13 citations
  5. 5Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel1995 · 11 citations