Population
Guinea pig ventricular myocytes
Design
Preclinical
Authors
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May guide selective antiarrhythmic development targeting Na-Ca exchanger-mediated Ca2+ release; leaves open translation to human arrhythmias.
R-56865 acts as an antiarrhythmic by inhibiting spontaneous Ca2+ release from the sarcoplasmic reticulum mediated by the Na(+)-Ca2+ exchanger in cardiac myocytes.
Ichikawa et al. (1994) studied this question.
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