Why the study?
Does R56865 alter cardiac sarcoplasmic reticulum Ca2+-release channel function and digoxin binding in cardiac SR vesicles?
Population
Cardiac sarcoplasmic reticulum vesicles and SR Ca2+-release channels incorporated into planar phospholipid…
Comparison
R56865 (0.5-50 microM) vs Control conditions (absence of R56865)
Design
Preclinical
Authors
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Suggests R56865 may mitigate digoxin toxicity via SR modulation; hypothesis-generating in animals, clinical relevance unknown.
Does R56865 alter cardiac sarcoplasmic reticulum Ca2+-release channel function and digoxin binding in cardiac SR vesicles?
R56865 inhibits Ca2+ uptake into the SR and antagonizes digoxin binding at the SR Ca2+-release channel, providing a potential mechanism for its protection against glycoside-induced toxicity and arrhythmias.
McGarry et al. (1995) studied this question.
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