September 1, 1990Journal of Cardiovascular Pharmacology

R56865, a Potent New Antiarrhythmic Agent, Effective During Ischemia and Reperfusion in the Rat Heart

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Why the study?

Does R56865 reduce ischemia- and reperfusion-induced ventricular tachycardia and fibrillation in rat hearts?

Structured PICO

Does R56865 reduce ischemia- and reperfusion-induced ventricular tachycardia and fibrillation in rat hearts?

Population

Anesthetized rats (4 groups, n=12 per group) and isolated rat hearts (5 groups, n=12 per group) subjected to 5- or 30-min coronary artery ligation and reperfusion.

Intervention

R56865 (0.5 or 2 mg/kg i.v. bolus in vivo; 10^-7, 10^-8, 10^-9 M in vitro) administered before ligation or throughout the experiment.

Comparator

Saline and dimethyl sulfoxide (DMSO) carrier (in vivo); unmodified buffer and buffer containing DMSO (in vitro).

Outcome

Incidence of reperfusion-induced and ischemia-induced ventricular tachycardia (VT) and ventricular fibrillation (VF).surrogate

R56865 demonstrates potent antiarrhythmic effects against ischemia- and reperfusion-induced ventricular arrhythmias in rat models.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

R56865 attenuates ischemia-induced VT/VF in rats; hypothesis-generating and should not yet inform clinical practice.

Cite This Study

Garner et al. (1990) studied this question.

synapsesocial.com/papers/6a23ce8b55bd20cf6fa63af5 https://doi.org/10.1097/00005344-199009000-00018

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R56865, a Potent New Antiarrhythmic Agent, Effective During Ischemia and Reperfusion in the Rat Heart

Structured PICO

Discussion

Implication

Cite This Study

R56865, a Potent New Antiarrhythmic Agent, Effective During Ischemia and Reperfusion in the Rat Heart

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider