What question did this study set out to answer?

To review the biological mechanisms and epidemiological evidence connecting dietary phytoestrogens, specifically isoflavonoids and lignans, to reduced risk of hormone-dependent cancers.

March 1, 1995Journal of NutritionOpen Access

Soybean Phytoestrogen Intake and Cancer Risk

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Authors

ČHČila HermanJohns Hopkins University TAT. AdlercreutzHelsinki University Hospital BGBarry R. GoldinNovosibirsk State Medical University

Discussion

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Implication

Narrative review demonstrates cancer-protective actions of dietary phytoestrogens in human populations, suggesting soy isoflavonoids and lignans lower malignancy risk.

Key Points

To review the biological mechanisms and epidemiological evidence connecting dietary phytoestrogens, specifically isoflavonoids and lignans, to reduced risk of hormone-dependent cancers.
Synthesized findings from biochemical, cellular, and epidemiological studies evaluating dietary sources of phytoestrogens such as soybeans, whole grains, seeds, and nuts.
Analyzed metabolic conversion pathways by gut bacteria and the resulting biological effects on human cellular processes and cancer incidence across geographic regions.
Intestinal bacteria convert plant glycosides into biologically active diphenolic compounds with weak estrogenic and antioxidative activities, modulating sex hormone metabolism, intracellular enzymes, and protein synthesis.
Phytoestrogens directly suppress malignant cell proliferation and angiogenesis while encouraging cellular differentiation, corresponding with lower cancer incidence in populations with high intake.

Cite This Study

Herman et al. (1995) studied this question.

synapsesocial.com/papers/6a7e431e19e76f2bf2990acb https://doi.org/10.1093/jn/125.3_suppl.757s

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Implication

Narrative review demonstrates cancer-protective actions of dietary phytoestrogens in human populations, suggesting soy isoflavonoids and lignans lower malignancy risk.

Soybean Phytoestrogen Intake and Cancer Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

Soybean Phytoestrogen Intake and Cancer Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

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