Patients with COPD who develop pulmonary embolism exhibit significantly decreased levels of endogenous anticoagulant proteins (Protein C and Protein S) compared to those with COPD alone, suggesting an underlying hypercoagulable state.
May indicate hypercoagulable state in COPD/PE; hypothesis-generating and leaves open whether testing alters management.
Introduction: Pulmonary embolism (PE) appears to be a major threat in patients who suffer of chronic obstructive pulmonary disease (COPD) and 13% of these patients suffer of embolism events. There are several causes for the development of a thrombophilic condition in patients with COPD, with abnormalities of the coagulation pathway being one of them. The aim of this study was to research the frequency of abnormalities in the anti-clotting proteins in COPD patients who have had a documented event of PE.
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Luis Maldonado Noriega (2012) studied this question.
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