Key result
PE complicates ~17% of acute COPD exacerbations and is linked to higher mortality.
Why the study?
The prevalence of pulmonary embolism in acute exacerbations of chronic obstructive pulmonary disease remains highly controversial.
What is the prevalence of pulmonary embolism in patients with AE-COPD, and does it increase the risk of mortality?
Meta-Analysis (n=3,170)
What is the prevalence of pulmonary embolism in patients with AE-COPD, and does it increase the risk of mortality?
Pulmonary embolism is highly prevalent (17.2%) in patients with acute exacerbation of COPD and is associated with significantly increased mortality, highlighting the need for clinical vigilance.
Answers are grounded in this paper and cite their sources.
Supports PE vigilance in AE-COPD; confirms mortality link and resolves prior study inconsistencies.
BACKGROUND: The prevalence of pulmonary embolism (PE) in the acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is highly controversial. We conducted a systematic review and meta-analysis to summarize the epidemiology and characteristics of PE with AE-COPD for current studies. METHODS: We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases for studies published prior to October 21, 2020. Pooled proportions with 95% confidence intervals (95% CIs) were calculated using a random effects model. Odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals were used as effect measures for dichotomous and continuous variables, respectively. RESULTS: A total of 17 studies involving 3170 patients were included. The prevalence of PE and deep vein thrombosis (DVT) in AE-COPD patients was 17.2% (95% CI: 13.4%-21.3%) and 7.1% (95% CI: 3.7%-11.4%%), respectively. Dyspnea (OR = 6.77, 95% CI: 1.97-23.22), pleuritic chest pain (OR = 3.25, 95% CI: 2.06-5.12), lower limb asymmetry or edema (OR = 2.46, 95% CI:1.51-4.00), higher heart rates (MD = 20.51, 95% CI: 4.95-36.08), longer hospital stays (MD = 3.66, 95% CI: 3.01-4.31) were associated with the PE in the AE-COPD patients. Levels of D-dimer (MD = 1.51, 95% CI: 0.80-2.23), WBC counts (MD = 1.42, 95% CI: 0.14-2.70) were significantly higher and levels of PaO2 was lower (MD = -17.20, 95% CI: -33.94- -0.45, P<0.05) in the AE-COPD with PE group. The AE-COPD with PE group had increased risk of fatal outcome than the AE-COPD group (OR = 2.23, 95% CI: 1.43-3.50). CONCLUSIONS: The prevalence of PE during AE-COPD varies considerably among the studies. AE-COPD patients with PE experienced an increased risk of death, especially among the ICU patients. Understanding the potential risk factors for PE may help clinicians identify AE-COPD patients at increased risk of PE. PROSPERO REGISTRATION NUMBER: CRD42021226568.
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Fu et al. (2021) conducted a meta-analysis in Acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) (n=3,170). Pulmonary embolism (PE) vs. AE-COPD without PE was evaluated on Prevalence of pulmonary embolism (PE) (95% CI 13.4%-21.3%). The pooled prevalence of pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease was 17.2%, and its presence increased the risk of death.
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