Why the study?
Endogenous Cushing's syndrome is characterized by an unfavorable cardiovascular and metabolic risk profile, but the potential adverse effects of hypercortisolism on myocardial function are not well known.
Does endogenous hypercortisolism impair left ventricular performance compared to healthy subjects and individuals with metabolic syndrome?
Does endogenous hypercortisolism impair left ventricular performance compared to healthy subjects and individuals with metabolic syndrome?
Endogenous hypercortisolism is associated with impaired left ventricular performance, as measured by myocardial work, beyond the effects of metabolic syndrome, and this impairment persists even after long-term biochemical remission.
Impaired myocardial work in Cushing syndrome signals possible subclinical dysfunction; leaves open whether cortisol normalization improves indices.
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Sahiti et al. (2025) studied this question.
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