Key result
Exogenous glucose oxidase restores hydrogen peroxide generation and bactericidal killing in chronic granulomatous disease leukocytes.
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Chronic granulomatous disease (CGD) is characterized by an inability of patients’ leukocytes to generate hydrogen peroxide and to kill non-peroxide-forming bacteria, such as staphylococci and serratiae. We have introduced glucose oxidase into CGD leukocytes in order to generate peroxide and thereby kill S. aureus and S. marcescens. These results support the concept that a leukocyte oxidative deficiency is primary to the pathogenesis of CGD.
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Johnston et al. (1970) studied Chronic granulomatous disease. Glucose oxidase introduction into CGD leukocytes was evaluated on Peroxide generation and bactericidal activity against S. aureus and S. marcescens. Introducing glucose oxidase into chronic granulomatous disease leukocytes enabled hydrogen peroxide generation and killing of S. aureus and S. marcescens.
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