Why the study?
Does cerebral blood flow and cerebrovascular reserve correlate with neuropsychological functioning in elderly individuals with atherosclerotic vascular disease?
Does cerebral blood flow and cerebrovascular reserve correlate with neuropsychological functioning in elderly individuals with atherosclerotic vascular disease?
In elderly patients with atherosclerotic vascular disease, PET-measured cerebral blood flow and cerebrovascular reserve correlate with cognitive performance.
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Supports hemodynamic-cognition link in atherosclerotic vascular disease; hypothesis-generating and requires longitudinal trials before clinical relevance.
This study was designed to determine the relationships between positron emission tomography (PET)-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular function would be significantly associated with neuropsychological functioning. Results showed that both baseline global cerebral blood flow and cerebrovascular reserve were significantly associated with global neuropsychological functioning, when controlling for age and sex. Cerebrovascular reserve was additionally associated with performance on measures of memory and attention. Additional research is needed to determine whether measures of cerebral blood flow can be used to predict cognitive decline.
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Moser et al. (2011) studied this question.
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