Palladium‐Catalyzed Amination of Aryl Halides—Catalysts on New Routes to Known Targets

It's the base that matters! Sodium tert ‐butoxide can be used to facilitate Pd‐catalyzed CN couplings directly with the amine. This was shown by research by Hartwig et al. and Buchwald et al. Thus, the use of ecologically unsound tin amides in the hetero‐Heck reaction may be avoided in future. Further improvement of the catalysts to make them industrially more interesting, and the extension of the method to CO couplings is eagerly awaited.