April 1, 1988Cardiovascular Research
Relation of monophasic action potential recorded with contact electrode to underlying transmembrane action potential properties in isolated cardiac tissues: a systematic microelectrode validation study
Population
Isolated canine cardiac tissue preparations (endocardium, epicardium, and free running Purkinje fibre)
Comparison
Monophasic action potential recording with… vs Transmembrane action potential recording with…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Validates contact-electrode monophasic recordings as surrogates for transmembrane potentials in canine tissues; leaves open translation to human electrophysiology.
Structured PICO
P
Population
Isolated canine cardiac tissue preparations (endocardium, epicardium, and free running Purkinje fibre)
I
Intervention
Monophasic action potential recording with contact non-suction electrodes
C
Comparator
Transmembrane action potential recording with standard microelectrodes
O
Outcome
Action potential duration at 50% and 90% repolarization (APD50 and APD90)surrogate
Monophasic action potentials recorded with contact electrodes accurately reflect the underlying transmembrane action potential durations and abnormal automatic activities in isolated canine cardiac tissues.
Cite This Study
Ino et al. (1988) studied this question.