Population
PC3 and LNCaP prostate cancer cell lines
Comparison
Conditioned-medium from LNCaP cells engineered… vs Control conditioned-medium
Design
Preclinical
Authors
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May support IGF-1R targeting in neuroendocrine prostate cancer; leaves open applicability beyond animal models.
Neuroendocrine-derived factors promote prostate cancer cell survival through cross-talk with IGF-1R signaling, mediated in part by PTPRF.
DaSilva et al. (2012) studied this question.
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