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May 12, 2006Journal of Applied Physiology300 citations

Aging Effects on Muscle Fiber Type and Contractile Function in Sprinters

Aging, muscle fiber type, and contractile function in sprint-trained athletes

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Authors

MKMarko T. KorhonenACAlexander CristeaMAMarkku Alén

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Overview

Cross-sectional study demonstrates age-related fast-fiber atrophy and slower contractile kinetics in male sprinters, indicating sprint training partially preserves aging muscle function.

Key Points

  • To examine the effects of aging on muscle fiber-type distribution, cross-sectional area, myosin heavy chain isoforms, and single-fiber contractile properties in sprint-trained athletes.
  • Obtained vastus lateralis muscle biopsies from 91 male sprinters aged 18 to 84 years and analyzed fiber types and myosin heavy chain (MHC) isoforms using ATPase histochemistry and SDS-PAGE.
  • Measured specific tension and maximum shortening velocity (Vo) in 144 single skinned fibers from younger (18–33 yr, n = 8) and older (53–77 yr, n = 9) sprinters, alongside knee extensor isometric force tests.
  • Type II fiber cross-sectional area decreased with age (P < 0.001) alongside increased MHC I (P < 0.01) and decreased MHC IIx (P < 0.05), whereas type I cross-sectional area and MHC IIa content remained unchanged.
  • Maximum shortening velocity of type I fibers was significantly lower in older sprinters (P < 0.05), and maximal isometric force (P < 0.001) and normalized rate of force development (P < 0.05) declined with age.

Cite This Study

Korhonen et al. (2006) studied this question.

synapsesocial.com/papers/6a7e53729094135e0b3c3c21https://doi.org/10.1152/japplphysiol.00299.2006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Muscle Fiber Types: How Many and What Kind?1970 · 2,158 citations
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  4. 4Age, Isometric Strength, Rate of Tension Development and Fiber Type Composition1981 · 86 citations
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