Why the study?
The effects of subclinical increases in blood pressure (prehypertension) and the combined effect of race and prehypertension on cutaneous sensory nerve-mediated and nitric oxide-dependent vasodilation were unknown.
Does prehypertension reduce cutaneous sensory nerve-mediated and NO-dependent vasodilation in non-Hispanic black and white populations?
Does prehypertension reduce cutaneous sensory nerve-mediated and NO-dependent vasodilation in non-Hispanic black and white populations?
Prehypertension is associated with reduced cutaneous sensory nerve-mediated and NO-dependent vasodilation, particularly in non-Hispanic blacks, suggesting early microvascular dysfunction.
Should not yet change prehypertension management; leaves open causal mechanisms and racial disparities in microvascular function.
Overt hypertension is known to reduce cutaneous sensory nerve-mediated and nitric oxide (NO)-dependent vasodilation, but the effect of subclinical increases in blood pressure (i.e., prehypertension) is unknown. The combined effect of race and prehypertension is also unknown. In this study, we found that prehypertension reduces cutaneous sensory nerve-mediated and NO-dependent vasodilation in both non-Hispanic white and black populations, with the greatest reductions observed in prehypertensive non-Hispanic blacks.
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Wong et al. (2020) studied this question.
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