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October 11, 2011PLoS MedicineOpen Access

Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia: Estimating the Burden of Antibiotic Resistance in Europe

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Authors

MKMarlieke E.A. de KrakerPDPeter DaveyHGHajo Grundmann

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Overview

Prospective surveillance study finds substantial excess mortality and healthcare costs from resistant bacteremia across Europe, highlighting a growing threat from Gram-negative pathogens.

Key Points

  • To determine the excess mortality, additional hospital bed-days, and associated hospital costs caused by bloodstream infections with MRSA and third-generation cephalosporin-resistant Escherichia coli in 31 European countries.
  • Extrapolated bloodstream infection incidence across 31 countries participating in the European Antimicrobial Resistance Surveillance System (EARSS) using surveillance prevalence data and national healthcare statistics.
  • Calculated excess 30-day mortality and extra hospital days using parameters derived from prospective cohort studies conducted in EARSS-participating hospitals in 2007.
  • Estimated attributable hospital costs using an established cost model and projected future prevalence trajectories through 2015 based on surveillance trends.
  • In 2007, 27,711 episodes of MRSA bacteremia resulted in 5,503 excess deaths, 255,683 excess hospital bed-days, and attributable costs of €44.0 million ($63.1 million).
  • In 2007, 15,183 episodes of G3CREC bacteremia led to 2,712 excess deaths, 120,065 excess hospital days, and attributable costs of €18.1 million ($29.7 million).
  • Surveillance projections indicate that bloodstream infections caused by G3CREC are expanding rapidly and will outnumber MRSA bloodstream infections in the near future.

Cite This Study

Kraker et al. (2011) studied this question.

synapsesocial.com/papers/6a7e5766bf2fd941fe8f4b73https://doi.org/10.1371/journal.pmed.1001104
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