Population
Macrophage cells (in vitro model)
Comparison
Interferon-gamma (IFN-gamma) exposure vs Unexposed cells
Design
Preclinical
Authors
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May implicate IFN-gamma in atherogenesis via Sp1/Sp3; hypothesis-generating in animal models, human relevance remains open.
The study reveals a novel mechanism for IFN-gamma-mediated regulation of macrophage gene transcription via Sp1 and Sp3, which may be relevant to the pathogenesis of atherosclerosis.
Hughes et al. (2002) studied this question.
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