Population
Inbred mouse strains differing in susceptibility to diet-induced atherosclerosis
Comparison
Atherosclerosis-susceptible mouse strains vs Atherosclerosis-resistant mouse strains
Design
Preclinical
Authors
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May implicate macrophage LPL in murine atherosclerosis susceptibility; leaves open human relevance and need for translational studies.
High macrophage LPL expression and secretion are associated with susceptibility to atherosclerosis in inbred mouse strains, suggesting a contributive role for LPL in atherosclerosis development.
Renier et al. (1993) studied this question.
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