Why the study?
Does PAI-1 deficiency lead to the spontaneous development of cardiac fibrosis and altered microvascular integrity in mice?
Population
PAI-1 deficient (PAI-1(-/-)) mice, including a subset evaluated at 12 weeks of age
Design
Preclinical
Follow-up
Evaluated at 12 weeks of age and with aging
Authors
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Does not support PAI-1 inhibition in patients; leaves open its cardioprotective role in human cardiac fibrosis for translational study.
Does PAI-1 deficiency lead to the spontaneous development of cardiac fibrosis and altered microvascular integrity in mice?
PAI-1 is cardioprotective in mice by maintaining microvascular integrity, and its deficiency predisposes to inflammation and spontaneous cardiac fibrosis.
Xu et al. (2009) studied this question.
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