February 1, 1993Clinical Endocrinology
Atrial natriuretic factor reduces vasopressin and angiotensin II but not the ACTH response to acute hypoglycaemic stress in normal men
Why the study?
Does atrial natriuretic factor reduce the vasopressin and hypothalamic-pituitary-adrenal response to insulin-induced hypoglycaemia in normal men?
Population
Normal men
Comparison
Atrial natriuretic factor 2.5 pmol/kg/min for… vs Vehicle alone (placebo)
Design
RCT, randomized, Single blind, placebo controlled
Follow-up
120 minutes
Authors
Discussion
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Member takes
Implication
ANF selectively attenuates vasopressin and angiotensin II responses to hypoglycaemia without HPA effects; extends evidence for its targeted neuroendocrine modulation in stress.
Structured PICO
Does atrial natriuretic factor reduce the vasopressin and hypothalamic-pituitary-adrenal response to insulin-induced hypoglycaemia in normal men?
P
Population
Normal men
I
Intervention
Atrial natriuretic factor (ANF) 2.5 pmol/kg/min for 120 minutes commencing 30 minutes before bolus administration of insulin (0.15 U/kg body weight)
C
Comparator
Vehicle alone (placebo)
O
Outcome
Vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemiasurrogate
Physiological increments of ANF attenuate vasopressin and angiotensin II responses to hypoglycaemia without inhibiting the hypothalamic-pituitary-adrenal axis or sympathetic activation.
Cite This Study
Wittert et al. (1993) studied this question.