February 1, 2005Journal of Clinical MicrobiologyOpen Access

Self-Assembly of the Recombinant Capsid Protein of a Bovine Norovirus (BoNV) into Virus-Like Particles and Evaluation of Cross-Reactivity of BoNV with Human Noroviruses

View Full Paper

Ask AI

Bookmark

Population

Recombinant baculoviruses expressing capsid genes of Bo/CV186-OH/00/US, and serum/antigen from calves…

Design

Preclinical

Authors

MHMyung Guk HanKorea Disease Control and Prevention Agency QWQ. WangGuizhou University JSJeffrey SmileyUniversity of Kentucky

Discussion

Member takes

Implication

Supports BoNV VLP-based ELISAs for veterinary use; leaves open translation to human norovirus diagnostics.

Structured PICO

Population

Recombinant baculoviruses (rCV186-OH and rJNCV) expressing capsid genes of Bo/CV186-OH/00/US (bovine norovirus GIII/2), and serum/antigen from calves infected with Bo/CV186-OH/00/US

Intervention

Generation of recombinant baculoviruses to express capsid genes and self-assembly into virus-like particles (VLPs)

Outcome

Self-assembly into VLPs and cross-reactivity with human norovirusessurrogate

Recombinant bovine norovirus capsid proteins can self-assemble into VLPs, which are useful for serological assays and demonstrate no significant antigenic cross-reactivity with tested human noroviruses.

Cite This Study

Han et al. (2005) studied this question.

synapsesocial.com/papers/6a7e60623eabdb005bb29fa5 https://doi.org/10.1128/jcm.43.2.778-785.2005

View Full Paper

Ask AI

Bookmark

Self-Assembly of the Recombinant Capsid Protein of a Bovine Norovirus (BoNV) into Virus-Like Particles and Evaluation of Cross-Reactivity of BoNV with Human Noroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Self-Assembly of the Recombinant Capsid Protein of a Bovine Norovirus (BoNV) into Virus-Like Particles and Evaluation of Cross-Reactivity of BoNV with Human Noroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider