Why the study?
Does oral propranolol alter the fractal properties of heart rate variability in healthy volunteers?
Population
10 healthy volunteers
Comparison
Oral propranolol (2 x 80 mg/day) in 5 subjects vs Placebo
Design
Other
Follow-up
2-3 hours
Authors
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Fractal HRV properties persist after propranolol in healthy volunteers; leaves open sympathetic modulation of 1/f dynamics in cardiovascular disease.
Does oral propranolol alter the fractal properties of heart rate variability in healthy volunteers?
The inversely proportional frequency (1/f) spectrum in human resting HRV is due to underlying random fractal dynamics, which are not significantly modulated by the sympathetic nervous system.
Yamamoto et al. (1994) studied this question.
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