What question did this study set out to answer?

To review the role of nicotinamide phosphoribosyltransferase (Nampt) in maintaining intracellular NAD levels and orchestrating downstream metabolic, inflammatory, and oncogenic signaling pathways.

December 23, 2009Cancer Research

The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer

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To review the role of nicotinamide phosphoribosyltransferase (Nampt) in maintaining intracellular NAD levels and orchestrating downstream metabolic, inflammatory, and oncogenic signaling pathways.
Synthesized mechanistic findings on Nampt-dependent biosynthesis of intracellular nicotinamide adenine dinucleotide (NAD).
Assessed biochemical pathways linking NAD availability to the regulation of NAD-dependent enzymes governing cell viability and inflammatory responses.
Nampt serves as an essential enzymatic regulator required to sustain intracellular NAD pools.
Fluctuations in Nampt-mediated NAD availability directly govern downstream NAD-dependent enzymes that regulate cell survival cascades and inflammatory mediators.
Pharmacological inhibition of Nampt displays dual utility as an anti-inflammatory and antitumor therapeutic strategy.

Authors

MGMara GallíParks Victoria FGFrédéric Van GoolIntegrated BioTherapeutics (United States)ARAnthony RongvauxCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

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Implication

Narrative review reveals Nampt-driven NAD modulation controls inflammatory and survival pathways in cells, highlighting its promise as a dual antitumor and anti-inflammatory drug target.

Cite This Study

Gallí et al. (2009) studied this question.

synapsesocial.com/papers/6a7e64e17d56b70fde399162 https://doi.org/10.1158/0008-5472.can-09-2465

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Implication

Narrative review reveals Nampt-driven NAD modulation controls inflammatory and survival pathways in cells, highlighting its promise as a dual antitumor and anti-inflammatory drug target.

The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer

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Discussion

Implication

Cite This Study

The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer

Key Points

Discussion

Implication

Cite This Study

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