Why the study?
Does dexrazoxane prevent collagen network alterations and MMP changes in a rabbit model of daunorubicin-induced cardiomyopathy?
Population
Chinchilla male rabbits (model of non-ischemic, anthracycline-induced chronic cardiomyopathy)
Comparison
Daunorubicin with or without the… vs Control (saline in the same schedule)
Design
Preclinical
Follow-up
10 weeks
Authors
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Dexrazoxane may attenuate anthracycline fibrosis in rabbits; leaves open translation to human cardioprotection.
Does dexrazoxane prevent collagen network alterations and MMP changes in a rabbit model of daunorubicin-induced cardiomyopathy?
In a rabbit model of daunorubicin-induced cardiomyopathy, dexrazoxane co-administration prevented anthracycline-induced myocardial fibrosis and collagen accumulation.
Adamcová et al. (2010) studied this question.
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