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November 8, 2012Pharmaceutical BiologyOpen Access

Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats

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Why the study?

Does proanthocyanidins prevent doxorubicin-induced cardiotoxicity in male Sprague-Dawely rats?

Population

Male Sprague-Dawely rats

Comparison

Proanthocyanidins once daily for 10 days with… vs Doxorubicin 15 mg/kg i.p. alone…

Design

Preclinical

Follow-up

10 days

Authors

EAElsayed M. AmmarSSShehta A. SaidSESally L. El-Damarawy

Discussion

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Overview

May attenuate doxorubicin cardiotoxicity in rats; leaves open clinical translation and human trials.

Structured PICO

Does proanthocyanidins prevent doxorubicin-induced cardiotoxicity in male Sprague-Dawely rats?

P
Population
Male Sprague-Dawely rats
I
Intervention
Proanthocyanidins (70 mg/kg, orally) once daily for 10 days with doxorubicin 15 mg/kg i.p. as a single dose on the 7th day
C
Comparator
Doxorubicin 15 mg/kg i.p. alone, proanthocyanidins alone, and untreated control
O
Outcome
Doxorubicin-induced cardiotoxicity measured by serum biomarkers, cardiac tissue antioxidant status, ECG, and aconitine-induced cardiotoxicitysurrogate

Grape-seed proanthocyanidins demonstrate potential as a cardioprotective agent against doxorubicin-induced cardiotoxicity in a rat model.

Cite This Study

Ammar et al. (2012) studied this question.

synapsesocial.com/papers/6a7e667afff4c9ddccc7697dhttps://doi.org/10.3109/13880209.2012.729065
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