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October 20, 2025Poultry ScienceOpen Access

Recombinant LAB vector engineered to secrete chicken IFN-λ3 induces an early but sustained activation of antiviral host responses against AIV infection

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Why the study?

Frequent avian influenza virus outbreaks in poultry lack effective vaccines and face antiviral resistance, making host-targeted mucosal cytokine therapies like ChIFN-λ3 a needed alternative.

Population

Chickens infected with avian influenza virus

Comparison

Mucosal administration of recombinant Lactococcus lactis secreting ChIFN-λ3 vs controls

Design

Preclinical animal study

Authors

SBSucharita BhowmickIndian Institute of Science Education and Research KolkataSYSandeep YadavIndian Institute of Science Education and Research KolkataAVAparna VarmaIndian Institute of Science Education and Research Kolkata

Discussion

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Member takes

Implication

Hypothesis-generating for mucosal antivirals in poultry; leaves open translation to other species or settings.

Structured PICO

P
Population
Chickens infected with avian influenza virus (A/turkey/Wisconsin/1/1966/H9N2)
I
Intervention
Mucosal administration of recombinant Lactococcus lactis (L. lactis) secreting chicken Type III Interferon (ChIFN-λ3)
O
Outcome
Avian influenza virus replication and shedding, and histopathological tissue integritysurrogate

Mucosal delivery of L. lactis secreting ChIFN-λ3 elicits a strong antiviral host defense against avian influenza virus infection in chickens, offering a potential alternative to conventional antivirals.

Cite This Study

Bhowmick et al. (2025) studied this question.

synapsesocial.com/papers/6a7e66ad1fdb7ee677c76f0fhttps://doi.org/10.1016/j.psj.2025.105973
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