The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits
Population
Escherichia coli, infected cells, and uninfected cell lines stably transfected with the US11 gene
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform HSV therapy; leaves open US11's role in modulating host translation during infection.
Structured PICO
P
Population
Escherichia coli, infected cells, and uninfected cell lines stably transfected with the US11 gene
I
Intervention
Expression of US11 fusion protein and generation of anti-US11 monoclonal antibody
O
Outcome
Localization and association of US11 protein
The herpes simplex virus 1 US11 protein is a virion component that associates with ribosomal 60S subunits and localizes to nucleoli without requiring other viral functions.
Cite This Study
Roller et al. (1992) studied this question.