May 1, 1980Arthritis & Rheumatism
Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis
Authors
Discussion
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Implication
Case investigation demonstrates elevated collagenase and prostaglandin E2 secretion in chronic Lyme arthritis synovium, indicating a shared joint destruction pathway with rheumatoid arthritis.
Key Points
- To characterize the pathological and biochemical properties of proliferative synovial tissue from a patient with chronic, erosive Lyme arthritis.
- Obtained proliferative synovium via synovectomy from a patient with chronic Lyme arthritis and radiographic evidence of bony erosion.
- Cultured synovial cells for 8 days to measure production of collagenase, prostaglandin E2, and proteinases, and characterized the synovial lymphocyte population.
- Cultured synovial cells secreted high levels of collagenase and prostaglandin E2, accompanied by low levels of neutral and acid proteinases.
- Synovial tissue lymphocytes consisted of 67% T cells and 19% B cells within pannus tissue adherent to eroded cartilage and bone, morphologically resembling rheumatoid arthritis.
Cite This Study
Steere et al. (1980) studied this question.