The Japan Morning Surge-1 (JMS-1) Study: Protocol Description

Target 600 hypertensive outpatients with elevated morning systolic blood pressure (≥135 mmHg) assessed by self-measured home monitoring, on stable antihypertensive medication. Exclusions: arrhythmia, chronic inflammatory disease, and taking alpha-blockers or beta-blockers.

Doxazosin 1 mg/day taken just before going to bed, increased to 2 mg/day and 4 mg/day, with a beta-blocker added after a 1-month interval until morning systolic blood pressure is controlled to less than 135 mmHg.

Continuation of the antihypertensive treatment received at enrollment for 6 months.

Differences in markers of hypertensive target organ damage, such as brain natriuretic peptide and the urinary albumin excretion/creatinine ratio.surrogate