Population
Cerebellar Purkinje cells dissociated from normal, tottering, and leaner mice, and baby hamster kidney cells…
Comparison
Tottering and leaner mutations in the P/Q-type… vs Normal/wild-type Ca2+ channels
Design
Preclinical
Authors
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Tottering mutations directly impair P/Q Ca channel function in Purkinje cells; leaves open translation to human cerebellar channelopathies.
Single tottering mutations in the P/Q-type Ca2+ channel are directly responsible for reduced current density and altered gating behavior, leading to neuropathic phenotypes.
Wakamori et al. (1998) studied this question.
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